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Medical Management of Hyperlipidemias

Drug therapy Hyperlipidemias refer to the elevation of cholesterol and/or triglycerides in your blood. In some individuals, only the cholesterol or triglycerides are elevated, in others, both are elevated. Hence hyperlipidemia is used as a term to encompass all elevations of either cholesterol or triglycerides or both. Drugs for hypercholesterolemia Hypercholesterolemia refers to the elevation of cholesterol in your blood and is associated with the increase in your LDL which carries most of your cholesterol. Treatment for elevated cholesterol is recommended for any adult patient when your LDL cholesterol level remains greater than 4.9 mmol/L (190 mg/dL) or greater than 4.1 mmol/L (160 mg/dL) in the presence of two or more risk factors as mentioned in the preceding after a sufficient trial of at least 3 months of diet therapy alone. If there are clinical indications that you have been suffering from IHD, drug therapy will be started if your LDL cholesterol level is 3.4 mmol/L (130 mg/dL) or greater. There are three groups of drugs used to lower your LDL cholesterol. These are: -bile acid-binding resins -nicotinic acid -HMG-CoA reductase inhibitors. The resins act by enhancing sterol excretion and indirectly increasing LDL receptor-mediated catabolism of circulating LDL. These drugs have been proven by clinical trials to be safe and effective; thus, they can be used for children who have been suffering from familial hypercholesterolemia, and for primary prevention of IHD in young adults.